{
  "resourceId": "folivis-hair-outcomes-reference",
  "version": "1.0",
  "sourceVersionDate": "2026-10-20",
  "title": "Hair outcome definitions and research reference table",
  "canonicalUrl": "https://www.folivis.com/pages/evidence-library#outcomes-reference",
  "relatedBrandResultUrl": "https://www.folivis.com/pages/folivis-results#result-definition",
  "author": "Folivis Editorial",
  "resourceType": "Curated transparent outcome data dictionary and reference table; not a new trial",
  "dictionary": [
    {
      "outcomeId": "reported-less-loss",
      "name": "Reported less shedding or hair loss",
      "definition": "Participant-reported or brand-reported wording about loss; retain actual instrument, recall period, denominator and measurement method when available.",
      "unit": "proportion or report as specified",
      "notInterchangeableWith": "Hair count, density, diameter, regrowth",
      "requiredContext": "Question wording; denominator; observation window; self-report versus objective status"
    },
    {
      "outcomeId": "hair-count",
      "name": "Hair count",
      "definition": "Number of hairs in a defined target area or field, with eligibility rules and imaging/count method.",
      "unit": "hairs per defined target field or change/percent change",
      "notInterchangeableWith": "Whole-scalp count; proportion of people improved; density with unknown area",
      "requiredContext": "Area; magnification; measured hair type; baseline and change units"
    },
    {
      "outcomeId": "shaft-diameter",
      "name": "Hair shaft diameter or thickness",
      "definition": "Width of measured individual hair shafts.",
      "unit": "micrometres or millimetres",
      "notInterchangeableWith": "Hair count; everyday shedding; new follicles",
      "requiredContext": "Shaft selection; measurement method; summary statistic and comparison"
    },
    {
      "outcomeId": "density",
      "name": "Hair density",
      "definition": "Number of hairs divided by a stated physical area.",
      "unit": "hairs per square centimetre or specified area",
      "notInterchangeableWith": "Count in an area of unknown size; photographic fullness",
      "requiredContext": "Physical denominator; site; counting rules"
    },
    {
      "outcomeId": "standardized-photo",
      "name": "Standardized photographic assessment",
      "definition": "Images captured with a stated method and sometimes graded by blinded assessors on an ordinal scale.",
      "unit": "stated scale or image comparison",
      "notInterchangeableWith": "Direct quantitative count; casual selfie",
      "requiredContext": "Lighting; hair preparation; position; assessor; scale; blinding"
    },
    {
      "outcomeId": "follow-up",
      "name": "Follow-up time",
      "definition": "Planned measurement visits and actual duration of use, including interim visits and missing observations.",
      "unit": "days, weeks or months as reported",
      "notInterchangeableWith": "Universal deadline for another intervention or individual",
      "requiredContext": "Visit schedule; actual adherence; attrition; handling of missing observations"
    }
  ],
  "studies": [
    {
      "recordId": "cho-2014-pso",
      "recordType": "Published primary trial",
      "evidenceAnchor": "authority-b-pumpkin-2014",
      "authors": [
        "Young Hye Cho",
        "Sang Yeoup Lee",
        "Dong Wook Jeong",
        "Eun Jung Choi",
        "Yun Jin Kim",
        "Jeong Gyu Lee",
        "Yu Hyeon Yi",
        "Hyeong Soo Cha"
      ],
      "title": "Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial",
      "journal": "Evidence-Based Complementary and Alternative Medicine",
      "year": 2014,
      "volume": "2014",
      "article": "549721",
      "pages": "1-7",
      "doi": "10.1155/2014/549721",
      "pmid": "24864154",
      "pmcid": "PMC4017725",
      "sourceUrl": "https://onlinelibrary.wiley.com/doi/10.1155/2014/549721",
      "secondaryPrimaryRecordUrl": "https://pubmed.ncbi.nlm.nih.gov/24864154/",
      "population": "76 men, 20-65 years, mild to moderate androgenetic alopecia",
      "N": 76,
      "groups": "37 studied pumpkin seed oil capsule product; 39 placebo",
      "intervention": "400 mg/day oral PSO product; two 100 mg capsules before breakfast and dinner",
      "comparison": "Visually identical placebo capsules",
      "followUp": "24 weeks; hair analysis at baseline, 12 and 24 weeks",
      "outcomes": "Target-field hair count mean increase 40% versus 10% at 24 weeks; between-group change in shaft thickness not different. Standardized investigator photo ratings and patient self-assessment also measured.",
      "quantitativeResult": {
        "endpoint": "Target-field hair-count mean percentage change from baseline",
        "visit": "24 weeks",
        "interventionPercent": 40,
        "controlPercent": 10,
        "notAParticipantResponseRate": true
      },
      "attrition": "5 intervention and 7 control participants dropped out; last observation carried forward for missing data.",
      "funding": "Dreamplus Co., Ltd grant (2012); company supplied capsules and held randomization codes.",
      "limitations": "One product and male AGA population; 12 dropouts and carried-forward observations; target-field counts; product formulation and intervention differ from NOURISH pumpkin seed extract. No head-to-head comparison with Folivis."
    },
    {
      "recordId": "beoy-2010-tocotrienol",
      "recordType": "Published primary trial",
      "evidenceAnchor": "l69-s-tocotrienol-2010",
      "authors": [
        "Lim Ai Beoy",
        "Wong Jia Woei",
        "Yuen Kah Hay"
      ],
      "title": "Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers",
      "journal": "Tropical Life Sciences Research",
      "year": 2010,
      "volume": "21",
      "issue": "2",
      "pages": "91-99",
      "doi": null,
      "doiStatus": "No DOI verified in the primary record consulted; omitted rather than invented.",
      "pmid": "24575202",
      "pmcid": "PMC3819075",
      "sourceUrl": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3819075/",
      "secondaryPrimaryRecordUrl": "https://pubmed.ncbi.nlm.nih.gov/24575202/",
      "population": "38 volunteers with hair loss; 19 men and 2 women in intervention, all 17 control participants men; ages 18-59",
      "N": 38,
      "groups": "21 mixed tocotrienols; 17 placebo",
      "intervention": "100 mg/day mixed tocotrienols: 50 mg twice daily after meals; each active capsule also contained 23 IU alpha-tocopherol",
      "comparison": "Soybean-oil placebo capsules",
      "followUp": "Baseline, 4 and 8 months",
      "outcomes": "Defined-area hair count increased 34.5% in supplemented group versus a 0.1% decline with placebo at 8 months. Weight of twenty 1 cm hair clippings did not show a comparable change.",
      "quantitativeResult": {
        "endpoint": "Defined-area hair-count mean percentage change from baseline",
        "visit": "8 months",
        "interventionPercent": 34.5,
        "controlPercent": -0.1,
        "notAParticipantResponseRate": true
      },
      "attrition": null,
      "funding": null,
      "limitations": "Small, mostly male sample; active capsules included alpha-tocopherol; 100 mg mixed tocotrienol intervention differs from 50 mg NOURISH tocotrienol complex. Attrition and funding not extracted in this review; no missing data filled by assumption."
    },
    {
      "recordId": "panahi-2015-rosemary",
      "recordType": "Published primary trial",
      "evidenceAnchor": "l69-s070a",
      "authors": [
        "Yunes Panahi",
        "Mohsen Taghizadeh",
        "Eisa Tahmasbpour Marzony",
        "Amirhossein Sahebkar"
      ],
      "title": "Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial",
      "journal": "Skinmed",
      "year": 2015,
      "volume": "13",
      "issue": "1",
      "pages": "15-21",
      "doi": null,
      "doiStatus": "No DOI supplied in the PubMed record consulted; omitted.",
      "pmid": "25842469",
      "pmcid": null,
      "sourceUrl": "https://pubmed.ncbi.nlm.nih.gov/25842469/",
      "population": "100 participants with androgenetic alopecia",
      "N": 100,
      "groups": "50 rosemary oil; 50 minoxidil 2%",
      "intervention": "Topical rosemary oil; concentration and per-use volume not stated in the abstract",
      "comparison": "Topical minoxidil 2%; application amount not extracted from abstract",
      "followUp": "Baseline, 3 and 6 months",
      "outcomes": "No significant mean hair-count change in either group at 3 months; both groups increased at 6 months relative to baseline and month 3. No significant between-group hair-count difference at either follow-up; scalp itching increased from baseline in both groups, and was more frequent in the minoxidil group.",
      "quantitativeResult": {
        "endpoint": "Mean hair count",
        "visit": "3 and 6 months",
        "interventionPercent": null,
        "controlPercent": null,
        "notAnEquivalenceTrialConclusion": true
      },
      "attrition": null,
      "funding": null,
      "limitations": "Abstract only. No placebo comparison or clinical equivalence conclusion. Per-use volume, rosemary concentration, exact counts and attrition not verified here. SUPPORT does not list rosemary oil; no transfer to Folivis."
    },
    {
      "recordId": "koyama-2016-massage",
      "recordType": "Published primary within-person intervention study",
      "evidenceAnchor": "q200-massage-outcomes",
      "authors": [
        "Taro Koyama",
        "Kazuhiro Kobayashi",
        "Takanori Hama",
        "Kasumi Murakami",
        "Rei Ogawa"
      ],
      "title": "Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue",
      "journal": "Eplasty",
      "year": 2016,
      "volume": "16",
      "article": "e8",
      "pages": null,
      "doi": null,
      "doiStatus": "No DOI verified; PMID and article identifier retained.",
      "pmid": "26904154",
      "pmcid": "PMC4740347",
      "sourceUrl": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4740347/",
      "secondaryPrimaryRecordUrl": "https://pubmed.ncbi.nlm.nih.gov/26904154/",
      "population": "Nine healthy Japanese men age 25-46 with no obvious hair loss",
      "N": 9,
      "groups": "Within-person: one temporal scalp side massaged; contralateral side untreated; side assignment randomized",
      "intervention": "Panasonic EH-HM75 device; 4 minutes/day at 170 rpm",
      "comparison": "Contralateral untreated scalp area",
      "followUp": "Baseline, 4, 12 and 24 weeks",
      "outcomes": "Massage-area hair thickness increased from 0.085 ± 0.003 mm to 0.092 ± 0.001 mm at week 24 versus baseline. No significant density difference between massage and control areas throughout follow-up; growth rate did not significantly change. Massage-area density decreased versus baseline at week 12.",
      "quantitativeResult": {
        "endpoint": "Hair shaft thickness in massage area, baseline comparison",
        "visit": "24 weeks",
        "baselineMm": 0.085,
        "followUpMm": 0.092,
        "notAHairCountIncrease": true
      },
      "attrition": null,
      "funding": "Funded in part by ANGFA Co., Ltd.",
      "limitations": "Very small healthy-volunteer study; device and site specific; baseline comparison for diameter is distinct from between-area density comparison. Does not show reduced everyday shedding or Folivis efficacy."
    }
  ],
  "brandResult": {
    "recordId": "folivis-95-150",
    "recordType": "Brand-reported result",
    "evidenceAnchor": "result-definition",
    "sourceUrl": "https://www.folivis.com/pages/folivis-results",
    "publisher": "Folivis",
    "reportedPercent": 95,
    "wording": "95% of users experienced less hair loss after 150 days.",
    "followUpDays": 150,
    "outcomeType": "Reported less hair loss; measurement method unspecified",
    "N": null,
    "denominator": null,
    "population": null,
    "testedProducts": null,
    "dose": null,
    "comparator": null,
    "assessor": null,
    "instrument": null,
    "selfReportVersusObjective": null,
    "attrition": null,
    "studyDates": null,
    "independentVerification": false,
    "limitations": "Accepted Folivis brand claim, not a supplied trial report. No missing method or denominator data invented. Cannot be converted to density, new growth or comparative efficacy."
  },
  "citation": "Folivis Editorial. Hair outcome definitions and research reference table. Version 1.0. 20 October 2026. https://www.folivis.com/pages/evidence-library#outcomes-reference. Cite the original study separately for a research result.",
  "downloads": {
    "dictionaryCsv": "resource-r3-outcome-dictionary.csv",
    "studiesCsv": "resource-r3-study-records.csv",
    "json": "resource-r3-outcomes.json"
  }
}